Yes, you can move the entire X-Plane 11 folder, provided you do not have the Steam version.
If you have the Steam version, it is still possible to move the files but you would have to do it through the Steam interface.
I am not sure I understand the end of your question concerning South America, but I would not recommend to transfer files from the global scenery. What can be done, though, is to place X-Plane 11 on a fast and "small" SSD and create shortcuts inside custom scenery folder that will target at heavy scenery packages saved on a big and "slow" Hard Drive. Be sure you completely understand name priorities and "Scenery Packs.ini" file before doing so, because it can become complex very quickly.
More details about that here :
Guillaume (not affiliated with Laminar Research)