I have the same issue with the same error in Win10.
I have to click "Understood" and the sim exits/crashes.
I have found that IF I disable the COM Port (COM1) in Windows device settings, I loose the controls and radios, but the sim loads, and does not crash.
I'm using PFC throttle/gear/flap with rudder trim, and a radio stack via COM port.
Wonder if there are particular port settings (BPS/DataBits/Parity/Stop/Flow) etc?