If the automatic crash report form comes up, be sure to fill it out and send it to us.
Otherwise, note that X-Plane only supports 1 GPU. Having 2 could be causing crashes.
You might also check your fps. Turn off VR, turn on fps output to the cockpit in settings, and make sure that you get around 45 fps without VR running. If not, try adjusting the graphics options. Note that VR is actually very CPU intensive.