Be sure to update the drivers to the video card. Also update Microsoft Visual C ++ 2010, DirectX and Microsoft.net framework from the official website of microsoft. This step will allow you to get rid of glitches, hangs and crashes when running on a PC.
Next, try to start the game as administrator. And try to put the compatibility mode of the game with WinXP or windows 7. This will increase your rights and increase the chances of launching X-Plane 11 Global - 64 Bit without errors and unnecessary problems.
Try to turn off the antivirus before starting the game. This will certainly weaken the protection of your computer, but it will help start the game without errors and brakes.
Try to enable DEP for the X-Plan11 Global-64 Bit exe file. This helped me at https://wedohomework.net/.
Check the system for errors and defragment. Go to the hard drive properties and select check for errors. And then defragment the drive. Ideally, a SSD drive is suitable for playing games. After installing it in 90% of cases - the game wont lag.