We have a quick start guide in the manual that is designed to get you flying as quickly as possible. This section covers setting up equipment.
I would recommend that you at least calibrate the yoke axes. Other than that, you can leave customizing buttons for later once you're more familiar with the simulator. Most of the important functions (brakes, flaps, etc) are already assigned to default keys. Here is a pdf guide to the most basic default keys you can print out to have on hand if it helps.
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