If you have multiple devices plugged in, or have assigned the same function to multiple axes, X-Plane now warns you, and they don't work. You can use the drop down in the top left corner (labeled "device") to check all the flight control devices you have plugged in.
If your product key has been disabled, please contact support at
[email protected] with the last 8 digits of your product key and the email you used to purchase it.