I Answer my selves here.
As long that the BUG where the NAV-button not work in 2D-mode off the FMS in a B747, you are not able to set the CRS ( = Course of Runway for the ILS landing.)
TO ALL - Do bug report on this, I think we must bomb the support to get them do something about it.
PS - The NAV-button works in B737-800 - where the setting of CRS is simple to set, also able to set from knob in cockpit.