Yeah, it's a little funky but that version of .NET it needs isn't included in Windows 10, so you have to install it still even though you have newer installed. (they install side by side)
Once its all installed, you should be albe to load up the "Saitek Radio Panel Test Page" app that comes with the driver and it should light up your led's with random flashing showing that it works. If you turn the knobs, you should also see it confirms the knobs working in the test app. If that doesn't work, you may not be getting enough power to your panel (i heard of people having problems when plugging into their yoke, hub, etc) so try plugging it directly into USB port on the PC.
Note: if you're not running the test app, or xplane, the led's on the panel won't light up, even though the panel is plugged in. The plugin needs to initialize at the startup of xplane, or via the test app for the led's to light up.