The message about leaving your region should only show up if you are using a regional edition of X-Plane. Did you purchase the regional edition originally and then recently upgrade to the digital download version?
I see your version is actually a little behind. Please try running the installer and opting to update to 10.42.
If that doesn't fix it, you can also try "resetting" your DRM. Go to your user -> Library -> Preferences and delete the 4 X-Plane files (Installer.prf, drm.prf, install_10.txt & xdd.prf). X-Plane should ask for your product key the next time you start and recreate these files.