A good place to look is at the preferences. Move the preferences folder (found in the Output folder) to the desktop, then restart X‑Plane and default preferences will be restored. If the default preferences do not fix your problem, you can simply replace them with the folder you moved to the desktop and restore your personalized settings.
The final common culprit is third party add ons, such as scenery and plugins. Try moving the Custom Scenery folder and plugins folder (found in the Resources folder) to the desktop, then restart X-Plane.
If the automatic crash report form comes up, be sure to fill it out & send it in. If it crashes in the same spot every time, after removing plugins & resetting preferences as explained above, you can file a bug report with the steps for us to investigate.