If deleting the preferences didn't help, you can try starting in safe mode. From the manual:
"If X‑Plane detects that it crashed the last time it was run, then on the next start, you have an option to reset the rendering settings. If you reset the settings, you might avoid a crash on startup if the rendering settings were the cause of the initial crash. Starting in X‑Plane 10.40, you may bring up the option to enter safe mode only if you start the sim with the shift key pressed down."
Please also double check that you aren't starting the 32 bit app on accident.