After 10.50 update from 10.45 - Sim flys fluidly - Mouse is absolutely MIA & gone from X-Plane's rendering??

Question

The Menu bar is there if you push the mouse up & the menus will respond to left click to open.  Once opened, the sub-menu bar navigation isn't accessible from using the keyboard arrow & if you can blindly stumble & find one of the "clickable" dialogue boxes, the left click on the mouse will actuate.

I've erased the "Preference" file from the Output directory.  

Where did the mouse go?

Comments

Interestingly, while the above idiosyncratic mouse dysfunction apply to the mouse being inside the main menu bar / sub menu region of the software,....when you hit escape from there & go to the flight dynamic the following operational differences apply:

• the mouse has to visual vestige in this environment.  For example..
  • No knob twisting arrows if you can stumble across the radio frequency set knobs or the DG heading to compass set knob.
  • I unplugged the mouse's USB cord to try to "reset" that paradigm but no joy!