I am not a tech nerd so i don't know if i could answer your question. i will give some suggestions however
1) Have you tried deleting your preferences (don't delete the folder, just the files inside then restart the sim)
2) If that doesn't work, you have a hardware issue or a virus. Experienced BSOD's? What computer do you have and specs?
3) Run the sim without any plugins installed and fly the same route and see if it happens.
I have 10.45 installed and haven't experienced this though i've been getting some BSOD's.