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Please see the official X‑Plane Support page for help.
I'm not with Laminar Research, just a fellow simmer in the UK and I apologise if this sounds like a daft question, but presumably both your X52 joystick and throttle quadrant have been calibrated properly within X-Plane 11 itself?
Presumably also, you haven't installed any third party software drivers to your operating system for these flight controllers?
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