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The plane is usually trimmed for takeoff settings. Once you are in cruise flight, you will need to trim the aircraft to fly straight and level. Letting go of the yoke will not normally just flight straight and level, unless you have an autopilot set up. Adjusting trims will be required.
A few observations:
I am not from Laminar Research; just a flight simmer from down under.
Have a look at the answer I have provided in the following link found at https://questions.x-plane.com/26378/i-have-a-ch-pro-pedals-problem
The software supplied with your hardware should be buried never to be seen again. The same action needs to be observed with other same brand hardware. If you are using instrument panels of the same name then bury that software and use the software supplied through the following link found at https://forums.x-plane.org/index.php?/files/file/14646-xsaitekpanels-linwinmac3264/
Good luck and I hope it solves your problem.
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